Epigenetic alterations are a widespread signature of human cancer, including generalized changes in DNA methylation status and variability. Whilst frequently affecting small to large regions of co-localized CpGs (i.e. CpG island shores), non adjacent loci also co-methylate.
To integrate localized and trans DNA methylation changes we are developing novel network-based analysis leveraging DNA methylation changes in sympathy across colorectal cancer patients. Aimed to detect both contiguous and non-contiguous effects, it extracts highly connected modules of co-methylated CpGs, whose DNA methylation profiles are next classified into discrete classes, allowing samples classification according to the DNA methylation status of their members.
The co-methylation browser will be released soon!