The co-methylation browser

Epigenetic alterations are a widespread signature of human cancer, including generalized changes in DNA methylation status and variability. Whilst frequently affecting small to large regions of co-localized CpGs (i.e. CpG island shores), non adjacent loci also co-methylate.

To integrate localized and trans DNA methylation changes we are developing novel network-based analysis leveraging DNA methylation changes in sympathy across colorectal cancer patients. Aimed to detect both contiguous and non-contiguous effects, it extracts highly connected modules of co-methylated CpGs, whose DNA methylation profiles are next classified into discrete classes, allowing samples classification according to the DNA methylation status of their members.

The co-methylation browser will be released soon!


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